A novel I-branching β-1,6-N-acetylglucosaminyltransferase involved in the human blood group I antigen expression
نویسندگان
چکیده
National Institute of Advanced Industrial Science and Technology (AIST), Glycogene Function Team, Research Center for Glycoscience (RCG), Tsukuba, Ibaraki, Japan. JGS Japan Genome Solutions, Inc., Hachioji, Tokyo, Japan. Fujirebio Inc., Frontier Research Division, Hachioji, Tokyo, Japan. Jichi Medical School, Division of Stem Cell Regulation, Minamikawachi, Tochigi, Japan. Amersham Biosciences KK, Tokyo, Japan. Gifu Prefecture Blood Center, Gifu, Japan. National Institute of Advanced Industrial Science and Technology (AIST), Cell Regulation Analysis Team, Research Center for Glycoscience (RCG), Tsukuba, Ibaraki, Japan.
منابع مشابه
Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen.
The human blood group i and I antigens are characterized as linear and branched repeats of N-acetyllactosamine, respectively. Conversion of the i to the I structure requires the activity of I-branching beta-1,6-N-acetylglucosaminyltransferase (IGnT). Thus the blood group I gene is assigned to encode a beta-1,6-N-acetylglucosaminyltransferase; however, its identity has not been confirmed. The nu...
متن کاملRED CELLS Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen
The human blood group i and I antigens are characterized as linear and branched repeats of N-acetyllactosamine, respectively. Conversion of the i to the I structure requires the activity of I-branching b-1,6-N-acetylglucosaminyltransferase (IGnT). Thus the blood group I gene is assigned to encode a b-1,6-N-acetylglucosaminyltransferase; however, its identity has not been confirmed. The null phe...
متن کاملN-acetylglucosaminyltransferase V negatively regulates integrin α5β1-mediated monocyte adhesion and transmigration through vascular endothelium.
Changes in the expression of glycosyltransferases that branch N-linked glycans are associated with many physiological and pathological events, such as cell adhesion, migration, proliferation and tumor cell malignancy. Here, the altered levels of N-acetylglucosaminyltransferase V (GnT-V) and its product β(1,6)-linked GlcNAc in monocytes were observed during inflammation. The effects of GnT-V and...
متن کاملSUSCEPTIBILITY OF HUMAN WM MELANOMA CELL LINES TO NK AND LAK CYTOTOXICITY AND THEIR RELEVANCE TO THE LEVEL OF MHC CLASS I AND ICAM-l ANTIGEN EXPRESSION
The effect of natural killer (NK) cells and lymphokine activated killer ( LAK) cells was studied on a group of human melanoma cell lines. Peripheral blood from healthy volunteers was utilized as a fresh source of natural killer cells and rhI L-2 for producing LAK cells. The cytotoxicity of effector cells was quantified using a 4 hour SI determining the density of antigen expression on tumor...
متن کاملThe molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataracts.
The human i and I antigens are characterized as linear and branched repeats of N-acetyllactosamine, respectively. Conversion of the i to the I structure requires I-branching beta-1,6-N-acetylglucosaminyltransferase activity. It has been noted that the null phenotype of I, the adult i phenotype, is associated with congenital cataracts in Asians. Previously, the identification of molecular change...
متن کامل